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 SeroVital HGH Review – Is it a Scam or Does It Work? Ingredients & More

Expert opinion:

Not Recommended


What is SeroVital? SeroVital HGH is marketed as an anti-aging treatment that not only reduces the appearance of wrinkles, but can also boost energy and promote fat loss.1 SeroVital HGH is distributed by SanMedica International. Containing a proprietary blend of amino acids, SeroVital claims to increase human growth hormone (HGH) levels within the body by 682%.1

HGH is a natural peptide hormone produced in the brain, and plays a major role in regulating several important bodily functions.2 HGH injections have become increasingly popular amongst adults looking to improve their inner and outer health. eroVital is advertised as an alternative to injection treatments, claiming supplementation of amino acids that stimulate HGH produces similar results to HGH injections.  The manufacturer states numerous benefits of taking SeroVital for men and women, including improved muscle mass, stronger bones, heightened sex drive, and youthful skin.1

Better Health Organization investigated the key ingredients found in SeroVital, weight loss and anti-aging evidence linked to HGH, as well as consumer experiences.  A comprehensive review of SeroVital reveals the effectiveness and side effects of this natural amino acid supplement.

SeroVital reviews
Do these SeroVital ingredients lead to significant SeroVital results

Formulated as a proprietary blend, the SeroVital ingredients are a collection of amino acids and traditional herbal extracts.

SeroVital Ingredients

What is in SeroVital? The primary ingredients in SeroVital HGH dietary supplement are combined in a proprietary blend of amino acids and herbs, which are believed to be the precursors to HGH production in the brain’s pituitary gland. SeroVital HGH ingredients claim to promote an improved hormonal balance that enhances health and vitality over time.

SeroVital Proprietary Blend: 2.9 g

L-Lysine HCl: Lysine is an essential amino acid for protein development and HGH production. Currently, there is conflicting research supporting supplementation of lysine to stimulate HGH production for both men and women.3,4

In the body, lysine helps form collagen and elastin, major components of healthy, youthful-looking skin.

L-Arginine HCl: A conditional amino acid, arginine is involved in producing various hormones and structural proteins, and research on arginine shows promise for providing anti-aging benefits. Improved sexual performance, boosted energy, and improved skin texture and circulation have been reported for continuous arginine supplementation.5

Oxoproline: Also known as pyroglutamic acid, oxoproline is a natural amino acid believed to have positive cognitive and hormonal impacts.18

N–Acetyl L-Cysteine: N-Acetyl L-Cysteine (NAC) is a potent antioxidant, and has shown positive prevention of age-related cognitive defects.6,7,8

L-Glutamine: L-Glutamine is a dietary amino acid known for its muscle building properties. Previous studies show glutamine effectively improved human growth hormone levels, however research on glutamine supplementation and increased lean muscle mass in adults is ongoing.9,10

Schizonepeta powder: Schizonepeta tenuifolia is an herb often used in Traditional Chinese medicine (TCM) for its anti-inflammatory and antioxidant properties. Studies confirm Schizonepeta powder has anti-aging properties, healing skin from symptoms such as dermatitis, eczema, and psoriasis.11,12

How to Take SeroVital HGH

According to the SeroVital label directions, adults should take 4 capsules by mouth with water on an empty stomach. SeroVital should be taken either in the morning two hours before breakfast, or two hours after dinner before bedtime. Users are instructed to not eat two hours before or after taking SeroVital and to not exceed 4 capsules in any 24-hour period.1

For those wondering how long does it take for SeroVital to work, the SeroVital website states HGH levels will be increased within 120 minutes.1 Individual results may vary.

SeroVital Side Effects

Is SeroVital safe? The company website claims SeroVital HGH side effects are rare, however customers taking medication or that have pre-existing medical conditions should consult a physician to reduce SeroVital risks.1

Studies on individual ingredients reveal there are potential side effects of SeroVital. The typical dose of L-arginine for bodybuilding is up to 15-18g/day.13 These doses are far greater than the total dose used in SeroVital. Even taking up to 20 g of arginine has been observed as safe for healthy adults.24 L-Lysine is generally safe for consumption with a recommended daily dose up to 3 g/day for adults.14 Large doses of lysine may result in gastrointestinal distress and reduced blood sugar for individuals with type 2 diabetes.15

N-Acetyl L-Cysteine can interfere with other nutrients including activated charcoal, and can also cause aggravated liver damage when combined with alcohol.16,17 L-Glutamine supplementation appears to be safe for adults, and there is limited evidence of significant adverse effects after taking glutamine long-term.19,20

SanMedica’s products are marketed as dietary supplements, and there is no requirement for SeroVital FDA approved status. SeroVital HGH reviews from independent consumers have experienced mild side effects, such as an upset stomach. However, there is no evidence of long-term adverse effects.

Does SeroVital Work?

On the SeroVital website, a study in which SeroVital was compared a to a placebo is described. The study results claim that a single dose of SeroVital improved GH levels 8-fold, and were significantly higher than the placebo group.1

All of this may leave users wondering does SeroVital really work? Below, we take a look at the science behind the individual ingredients to shed some light on these SeroVital results.

Studies reveal that L-arginine supplementation can increase peak growth hormone concentrations in the body up to 34-120%.21 Further research is needed to determine long-term effects of amino acid HGH therapy, as current HGH spikes do not increase whole-day growth hormone levels.22A recent study stated patients suffering from acne saw a 50% reduction in total skin lesions while supplementing N-acetylcysteine at 1200 mg/day for 8 weeks.23 L-Glutamine supplementation has been reported up to 14g/day, but the relative efficacy of glutamine for promoting weight loss and muscle mass improving muscle mass is unknown.24

SeroVital Reviews

Online, SeroVital reviews are mixed, with some consumers experiencing positive changes in energy and improved skin youthfulness. Positive SeroVital before and after comparisons can be found online, and some SeroVital bodybuilding forums suggest that the blend in SeroVital can also be useful for improving workout routines.

Where to Buy SeroVital

Wondering where can I buy SeroVital? SeroVital is available online through the company website. For the SeroVital price of shipping, new users are offered a 30-day supply to try the product out and decide if they’d like to continue using it.

Although other SeroVital retailers can be found in the United States, Australia, Canada, and the UK, the Better Health Organization recommends purchasing this supplement directly from the distributor. For additional questions or inquiries, SeroVital customer service contact information is provided on the company website.

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Scientific Research Referenced in this Article

  1. SanMedica International. (2017). SeroVital-HGH. Retrieved October 24, 2017 from – View Reference
  2. Strobl, J. S., & Thomas, M. J. (1994). Human growth hormone. Pharmacological Reviews46(1), 1-34. Retrieved October 24, 2017 from http://pharmrev.aspetjournals.org/content/46/1/1.
  3. Corpas, E., Blackman, M. R., Roberson, R., Scholfield, D., & Harman, S. M. (1993). Oral arginine-lysine does not increase growth hormone or insulin-like growth factor-I in old men. Journal of gerontology48(4), M128-M128. DOI: 1093/geronj/48.4.M128.
  4. Smeets, E. T., Schutzler, S. E., Wei, J. Y., Azhar, G., & Wolfe, R. R. (2017). Do anabolic nutritional supplements stimulate human growth hormone secretion in elderly women with heart failure?. Physiological reports5(15), e13366. DOI: 14814/phy2.13366
  5. Gad, M. Z. (2010). Anti-aging effects of L-arginine. Journal of Advanced Research1(3), 169-177.DOI: 1016/j.jare.2010.05.001
  6. Kolosova, N. G., Stefanova, N. A., Muraleva, N. A., & Skulachev, V. P. (2012). The mitochondria-targeted antioxidant SkQ1 but not N-acetylcysteine reverses aging-related biomarkers in rats. Aging (Albany NY)4(10), 686. DOI:  18632/aging.100493.
  7. Farr, S. A., Poon, H. F., Dogrukol‐Ak, D., Drake, J., Banks, W. A., Eyerman, E., … & Morley, J. E. (2003). The antioxidants α‐lipoic acid and N‐acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. Journal of neurochemistry84(5), 1173-1183. DOI: 1046/j.1471-4159.2003.01580.
  8. Kondratov, R. V., Vykhovanets, O., Kondratova, A. A., & Antoch, M. P. (2009). Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1. Aging (Albany NY)1(12), 979. DOI:18632/aging.100113.
  9. Welbourne, T. C. (1995). Increased plasma bicarbonate and growth hormone after an oral glutamine load. The American journal of clinical nutrition61(5), 1058-1061. Retrieved October 24, 20117 from http://ajcn.nutrition.org/content/61/5/1058.short.
  10. Candow, D. G., Chilibeck, P. D., Burke, D. G., Davison, S. K., & Smith-Palmer, T. (2001). Effect of glutamine supplementation combined with resistance training in young adults. European journal of applied physiology86(2), 142-149. DOI:1007/s00421-001-0523-y.
  11. Sohn, S. H., Cho, S., Ji, E. S., Kim, S. H., Shin, M., Hong, M., & Bae, H. (2012). Microarray analysis of the gene expression profile of HMC-1 mast cells following Schizonepeta tenuifolia Briquet treatment. Cellular immunology277(1), 58-65. DOI: 1016/j.cellimm.2012.05.012
  12. Choi, Y. Y., Kim, M. H., Kim, J. H., Jung, H. S., Sohn, Y., Choi, Y. J., … & Yang, W. M. (2013). Schizonepeta tenuifolia inhibits the development of atopic dermatitis in mice. Phytotherapy Research27(8), 1131-1135. DOI: 1002/ptr.4833.
  13. Grimble, G. K. (2007). Adverse gastrointestinal effects of arginine and related amino acids. The journal of nutrition137(6), 1693S-1701S. Retrieved October 24, 2017 from http://jn.nutrition.org/content/137/6/1693S.short.
  14. Lasser, R. P., Schoenfeld, M. R., & Friedberg, C. K. (1960). L-Lysine monohydrochloride: a clinical study of its action as a chloruretic acidifying adjuvant to mercurial diuretics. New England Journal of Medicine263(15), 728-733. DOI: 1056/NEJM196010132631504.
  15. Rubin, A. L., Spritz, N., Mead, A. W., Herrmann, R. A., Braveman, W. S., & Luckey, E. H. (1960). The use of L-lysine monohydrochloride in combination with mercurial diuretics in the treatment of refractory fluid retention. Circulation21(3), 332-336. DOI: 1161/01.CIR.21.3.332.
  16. Holdiness, M. R. (1991). Clinical pharmacokinetics of N-acetylcysteine. Clinical pharmacokinetics20(2), 123-134. DOI: 2165/00003088-199120020-00004.
  17. Wang, A. L., Wang, J. P., Wang, H., Chen, Y. H., Zhao, L., Wang, L. S., … & Xu, D. X. (2006). A dual effect of N-acetylcysteine on acute ethanol-induced liver damage in mice. Hepatology research34(3), 199-206.DOI: 1016/j.hepres.2005.12.005.
  18. Pederzolli, C. D., Mescka, C. P., Zandoná, B. R., de Moura Coelho, D., Sgaravatti, Â. M., Sgarbi, M. B., … & Dutra-Filho, C. S. (2010). Acute administration of 5-oxoproline induces oxidative damage to lipids and proteins and impairs antioxidant defenses in cerebral cortex and cerebellum of young rats. Metabolic brain disease25(2), 145-154. DOI: 1007/s11011-010-9190-1
  19. Garlick, P. J. (2001). Assessment of the safety of glutamine and other amino acids. The Journal of nutrition131(9), 2556S-2561S. Retrieved October 24, 2017 from http://jn.nutrition.org/content/131/9/2556S.short.
  20. Roth, E. (2008). Nonnutritive effects of glutamine. The Journal of nutrition138(10), 2025S-2031S. Retrieved October 24, 2017 from http://jn.nutrition.org/content/138/10/2025S.short.
  21. Collier, S. R., Casey, D. P., & Kanaley, J. A. (2005). Growth hormone responses to varying doses of oral arginine. Growth Hormone & IGF Research15(2), 136-139. DOI:1016/j.ghir.2004.12.004
  22. Besset, A., Bonardet, A., Rondouin, G., Descomps, B., & Passouant, P. (1982). Increase in sleep related GH and Prl secretion after chronic arginine aspartate administration in man. Acta endocrinologica99(1), 18-23. Retrieved October 24, 2017 from http://www.sciencedirect.com/science/article/pii/S1096637404001741.
  23. Sahib, A. S., Al-Anbari, H. H., Salih, M., & Abdullah, F. (2012). Effects of oral antioxidants on lesion counts associated with oxidative stress and inflammation in patients with papulopustular acne.  Clin. Exp. Dermatol. Res3, 163. DOI: 10.4172/2155-9554.1000163.
  24. Shao, A., & Hathcock, J. N. (2008). Risk assessment for the amino acids taurine, L-glutamine and L-arginine. Regulatory toxicology and pharmacology50(3), 376-399. DOI: 1016/j.yrtph.2008.01.004.

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