NeuroFuse Review: Side Effects & Ingredients – Is this Better than Adderall?
What is NeuroFuse? – NeuroFuse is a brain boosting, nootropic supplement that aims to improve cognitive functions, improve memory, boost energy, and relieve symptoms of brain fog.23
NeuroFuse is formulated with natural vitamins, antioxidants and herbal extracts that are required for cognition and nervous system health, as well as a proprietary blend containing eight ingredients that potentially improve overall cognitive abilities. Users are suggested to supplement NeuroFuse daily to enhance mental health and improve performance throughout the day.23
In this thorough NeuroFuse review, we analyze the individual ingredients, potential side effects and results to help answer the question, is NeuroFuse the most powerful nootropic supplement on the market today?
NeuroFuse’s goal is to provide consumers with brain boosting capabilities, while providing vital vitamins and amino acids for optimal health. Below, we analyze each key ingredient found in NeuroFuse and their potential to enhance cognitive performance.
Vitamin D3: 667 IU– Vitamin D3 is a critical component of long-term mental health, and low levels of vitamin D may lead to cognitive impairment with age.1Current research confirms vitamin D plays a vital role as a neuroactive steroid to promote brain development and cognitive function.2
Vitamin B6: 3.3 mg – Vitamin B6 promotes the production of neurotransmitters that support nerve function in the brain.3
Vitamin B12: 33.33 mcg – Vitamin B12 is another essential B vitamin that directly boosts brain health by promoting memory, focus, and concentration.5 Vitamin B12, similarly to B6, also supports the synthesis of brain boosting neurotransmitters serotonin and dopamine, positively affecting mood and mental health.6
Neurofuse Blend: 903 mg
Rhodiola rosea – Rhodiola rosea is a traditional Chinese herb that contains adaptogens that have pharmacological evidence of fighting stress and fatigue, while supporting mood and cognitive functions.7
Caffeine Anhydrous – A dehydrated form of caffeine, caffeine anhydrous is common in non-prescription medications and supplement capsules. Caffeine is widely used as a mental stimulant and can improve energy and physical performance.8
L-Theanine – L-Theanine is an amino acid predominantly found in green tea leaves, and has been examined for its ability to improve cognitive functions. Studies note that when L-Theanine is combined with caffeine, the combination may influence mental awareness, increase reaction times, and reduce symptoms of fatigue and stress.9,10
Bacopa Monierri – Bacopa monnierri is an Ayurveda herb traditionally used as a natural remedy for anxiety and improved memory. Modern research suggests Bacopa monnierri has potential to enhance cognitive performance with age.11,12
DMAE Bitartrate – DMAE bitartrate is an antioxidant that is naturally produced in small quantities in the brain. DMAE is believed to improve impaired cognitive function by increasing acetylcholine, the compound involved in memory, however further research is required to determine long-term effectiveness.13
Phosphatidylserine – Phosphatidylserine is a dietary supplement that’s claimed to reduce the risk of dementia and support healthy cognitive functions.14
Alpha Lipoic Acid – Alpha lipoic acid is an antioxidant that functions similarly to B vitamins. In animal studies, supplementing with alpha lipoic acid reduced oxidative stress in the brain, a factor that may contribute to neurodegenerative disorders.15
Choline Bitartrate – This natural compound is important for the normal function of cells and helps produce the neurotransmitter acetylcholine, which plays an active role in memory retention and overall cognitive enhancement.16,17
Huperzine A – Huperzine A is an herbal extract that has been shown to have neuroprotective properties.18
How to Use NeuroFuse
The NeuroFuse directions state to increase mental performance, users should begin taking 1-2 capsules of NeuroFuse per day, preferably with food. Depending on the preferred effect, tolerance and body type, individuals may increase the dose to 3-4 capsules per day. Users should not exceed 4 capsules per serving, or 6 capsules within 24 hours.
NeuroFuse Side Effects
Branded as NeuroFuse nootropic daily supplement, this product claims to naturally enhance cognition, memory, and performance safely. User reviews have not claimed to experience adverse side effects, although certain ingredients can produce side effects if taken in excess.
Vitamins D3, B6 and B12 are all quite low concentrations in NeuroFuse, and do not pose any potential side effects as all doses are safe for adult consumption. It is difficult to measure potential side effects of proprietary blends where ingredient doses are not disclosed. Phosphatidylserine is safe for consumption up to 300 mg, with potential side effects such as insomnia and upset stomach. Huperzine-A has only been studied for dosages up to 0.4 mg/day, and if used long-term it can lead to side effects including dizziness, upset stomach and nausea.20
Is NeuroFuse safe for consumers? While the FDA does not review every dietary supplement before it goes to market, they do need to approve all dietary ingredients. Every ingredient in NeuroFuse is considered safe and legal by the FDA.
Does NeuroFuse Work?
NeuroFuse is tailored to individuals who are seeking improved academic and work performance, reduced stress, and improved memory and focus. As noted in one NeuroFuse review (Reddit), some claim it Neurofuse results are an effective alternative to prescription study drugs.
In the body, vitamin B6 supports the production of neurotransmitters needed for proper brain function and development. Mild deficiencies in vitamin B6 may lead to short-term memory loss and difficulty concentrating. Low levels have also been noted in patients with depression.21
If users are deficient in vitamin B6 or B12, supplementation may restore natural levels and modestly improve memory and mood.
In clinical trials, caffeine and l-theanine have shown synergistic, cognitive effects when supplemented together. Successful doses of l-theanine (250 mg) and caffeine (150 mg), led to faster reaction time, numeric working and improved sentence verification. Increased alertness and reductions in fatigue and headaches were also noted.9
300 mg of bacopa monnieri has shown to improve word recall memory scores in patients 65 years and older.12 In another study, supplementing bacopa monnieri was reported to decrease the rate of forgetting in follow-up tests and patient questionnaires.11 While the exact dose in the Neurofuse formula is unknown, it’s possible it contains the same dose used in clinical trials.
NeuroFuse vs Adderall
Adderall is a prescribed pharmaceutical for patients who suffer from Attention Deficit Hyperactivity Disorder (ADHD).19 As Adderall is not readily available and does contain side effects for users, NeuroFuse could be considered a natural alternative to stimulate cognition without the risk of long-term addiction and harmful side effects.
Where to Buy NeuroFuse
For consumers looking to buy NeuroFuse , this product is currently available online through the brand’s website, with no Neurofuse GNC purchasing options to date. For the price of shipping and handling, users receive a full 30-day supply of the product, and can try it before deciding if they would like to continue using it.
Scientific Research Referenced in this Article
- Llewellyn, D. J., Lang, I. A., Langa, K. M., Muniz-Terrera, G., Phillips, C. L., Cherubini, A., … & Melzer, D. (2010). Vitamin D and risk of cognitive decline in elderly persons. Archives of internal medicine, 170(13), 1135-1141. doi:1001/archinternmed.2010.173
- Kesby, J. P., Eyles, D. W., Burne, T. H., & McGrath, J. J. (2011). The effects of vitamin D on brain development and adult brain function. Molecular and cellular endocrinology, 347(1), 121-127. https://doi.org/10.1016/j.mce.2011.05.014
- Bernstein, A. L. (1990). Vitamin B6 in clinical neurology. Annals of the New York Academy of Sciences, 585(1), 250-260. doi:1111/j.1749-6632.1990.tb28058.x
- Hvas, A. M., Juul, S., Bech, P., & Nexø, E. (2004). Vitamin B6 level is associated with symptoms of depression. Psychotherapy and psychosomatics, 73(6), 340-343. https://www.karger.com/Article/PDF/80386
- Tangney, C. C., Aggarwal, N. T., Li, H., Wilson, R. S., Decarli, C., Evans, D. A., & Morris, M. C. (2011). Vitamin B12, cognition, and brain mri measures a cross-sectional examination. Neurology, 77(13), 1276-1282. DOI:1159/000080386
- Valizadeh, M., & Valizadeh, N. (2011). Obsessive compulsive disorder as early manifestation of B12 deficiency. Indian journal of psychological medicine, 33(2), 203. doi: 4103/0253-7176.92051
- Panossian, A., Wikman, G., & Sarris, J. (2010). Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine, 17(7), 481-493. https://doi.org/10.1016/j.phymed.2010.02.002
- Trexler, E. T., Smith-Ryan, A. E., Roelofs, E. J., Hirsch, K. R., & Mock, M. G. (2016). Effects of coffee and caffeine anhydrous on strength and sprint performance. European Journal of Sport Science, 16(6), 702-710. https://doi.org/10.1016/j.biopsycho.2007.09.008
- Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., & Scholey, A. B. (2008). The effects of L-theanine, caffeine and their combination on cognition and mood. Biological psychology, 77(2), 113-122. http://www.sciencedirect.com/science/article/pii/S0301051107001573
- Kimura, K., Ozeki, M., Juneja, L. R., & Ohira, H. (2007). L-Theanine reduces psychological and physiological stress responses. Biological Psychology, 74(1), 39-45. https://doi.org/10.1016/j.biopsycho.2006.06.006
- Roodenrys, S., Booth, D., Bulzomi, S., Phipps, A., Micallef, C., & Smoker, J. (2002). Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology, 27(2), 279-281. doi:1016/S0893-133X(01)00419-5
- Calabrese, C., Gregory, W. L., Leo, M., Kraemer, D., Bone, K., & Oken, B. (2008). Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. The Journal of Alternative and Complementary Medicine, 14(6), 707-713. doi: 1089/acm.2008.0018
- Blin, O., Audebert, C., Pitel, S., Kaladjian, A., Casse-Perrot, C., Zaim, M., … & Marien, M. (2009). Effects of dimethylaminoethanol pyroglutamate (DMAE p-Glu) against memory deficits induced by scopolamine: evidence from preclinical and clinical studies. Psychopharmacology, 207(2), 201. Retrieved October 10, 2017 from https://link.springer.com/article/10.1007/s00213-009-1648-7
- Taylor, Christine L. (May 13, 2003). “Phosphatidylserine and Cognitive Dysfunction and Dementia (Qualified Health Claim: Final Decision Letter)”. Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration Retrieved October 10, 2017 from https://www.fda.gov/food/ingredientspackaginglabeling/labelingnutrition/ucm072999.htm
- Farr, S. A., Poon, H. F., Dogrukol‐Ak, D., Drake, J., Banks, W. A., Eyerman, E., … & Morley, J. E. (2003). The antioxidants α‐lipoic acid and N‐acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. Journal of neurochemistry, 84(5), 1173-1183. DOI: 1046/j.1471-4159.2003.01580.x
- Zeisel, S. H. (2000). Choline: needed for normal development of memory. Journal of the American College of Nutrition, 19(sup5), 528S-531S. http://dx.doi.org/10.1080/07315724.2000.10718976
- Meck, W. H., & Williams, C. L. (1997). Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory. Neuroreport, 8(13), 2831-2835. Retrieved October 10, 2017 from http://journals.lww.com/neuroreport/Abstract/1997/09080/Characterization_of_the_facilitative_effects_of.5.aspx
- Zangara, A. (2003). The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer’s disease. Pharmacology Biochemistry and Behavior, 75(3), 675-686. https://doi.org/10.1016/S0091-3057(03)00111-4
- Kolar, D. Keller, A. Golfinopoulos, M., Cumyn, L., Syer, C., & Hechtman, L. (2008). Treatment of adults with attention-deficit/hyperactivity disorder. Neuropsychiatr Dis Treat, 4(2), 389-403. Retrieved October 10, 2017 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518387/
- Bauer, B. A. (2014, November 25). Huperzine A: Can it treat Alzheimer’s? Retrieved October 10, 2017 from http://www.mayoclinic.org/diseases-conditions/alzheimers-disease/expert-answers/huperzine-a/faq-20058259
- University of Maryland Medical Center. (2015, August 5). Vitamin B6 (Pyridoxine). Retrieved October 10, 2017 from http://www.umm.edu/health/medical/altmed/supplement/vitamin-b6-pyridoxine
- University of Maryland Medical Center. (2015, October 19). Vitamin B12 (cobalamin). Retrieved October 10, 2017 from http://www.umm.edu/health/medical/altmed/supplement/vitamin-b12-cobalamin
- (2017). Neurofuse. Retrieved October 10, 2017 from – View Reference