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Instaflex Review: Ingredients, Side Effects, & Does It Work?

Expert opinion:

Not Recommended


Are you one of the many people who suffer from joint pain and stiffness? For many people, joint discomfort can hold them back from participating in many of the activities they enjoy doing.

What is Instaflex? – Marketed as a revolutionary joint supplement, Instaflex claims to improve joint flexibility, mobility, and relieve joint discomfort.1

Developed in Massachusetts and Utah, Instaflex is claimed to be made in a GMP facility that meets strict FDA guidelines.2 Formulated with natural ingredients, Instaflex joint relief is claimed to be effective for problematic areas such as the knees, hips, ankles, back and hands.2

In this Instaflex review you’ll learn more about the product and find out if it can help reduce pain and stiffness in your joints. We’ll also look at the ingredients and possible side effects to answer the question, is Instaflex safe to use?

instaflex reviews and is instaflex safe
Instaflex ingredients label and Instflex side effects

With eight natural ingredients, Instaflex uses a non-proprietary blend that’s designed to support healthy joints.

Instaflex Ingredients

What are the ingredients in Instaflex? There are eight key ingredients in Instaflex, each of which we’ve scientifically researched to see just how effective they can be when it comes to supporting joint health.  Here are the key ingredients, as outlined on the Instaflex ingredients label:

Glucosamine Sulfate: 1,500 mg – Glucosamine is naturally found in the body and is a combination of glucose and glutamine. It is found largely in the cartilage, and helps keep the joints resilient. Glucosamine is widely used as a natural supplement for degenerative joint disease symptoms, or to help reduce inflammation.3,4

Methylsulfonylmethane (MSM): 500 mg – Also known as MSM, methylsulfonylmethane is found in green fruits, plants, and vegetables. It is commonly used to relieve the symptoms of osteoarthritis, such as reducing pain and inflammation.5

In the body, salicine is converted into salicylate, which is similar to Aspirin.6

White Willow Bark Extract: 250 mg – White willow is an herb that is often used by natural health practitioners to alleviate pain, fevers or symptoms of osteoarthritis and rheumatoid arthritis. It contains salicine, which is attributed for its natural anti-inflammatory and analgesic properties.6

Ginger Root Extract: 250 mg – Ginger is a plant that has long been used in traditional herbal medicine. Known for its anti-inflammatory and anti-oxidative properties, increasing research notes it may be a natural therapeutic agent for a variety of conditions, including arthritis and rheumatism.7

Boswellia Serrata Extract: 125 mg – Boswellia serrata extract comes from a tree commonly found in India. It’s been traditionally used in folk medicine to reduce inflammation and inflammatory diseases.8

Turmeric Root Extract: 50 mg –  Used as a seasoning and therapeutic aid, turmeric is a plant that has long been used in Traditional Chinese Medicine (TCM) for its anti-inflammatory properties and natural arthritis relief.9

Cayenne Fruit: 50 mg – Cayenne is a plant that contains capsaicin, a phytochemical that is recognised for its anti-inflammatory and anti-oxidant effects on the body.10

Hyaluronic Acid: 4 mg – Hyaluronic acid is naturally found in the body and acts as a lubricant to the joints to reduce friction.11

Instaflex Joint Support Directions

According to the Instaflex directions, users should take 3 capsules daily with water. For the best results, Instaflex should be taken along with eating a healthy diet and maintaining a light exercise routine.

One bottle of Instaflex Joint Support (90 capsules) will provide users with a 30-day supply.

Instaflex Side Effects

As with taking any supplement, there are some possible side effects of Instaflex. While MSM is considered safe to use, some people may experience mild gastrointestinal upset and skin rashes.5 Boswellia serrata may also cause gastrointestinal discomfort for some people, but is otherwise well tolerated.12 Reports of mild diarrhea, upset stomach or nausea have been noted when taking turmeric and cayenne fruit.9,10 As white willow is similar to aspirin, those people who are allergic to aspirin, or should avoid blood thinners, should not use Instaflex. Otherwise, white willow is generally considered safe to use.6

While nonsteroidal anti-inflammatory drugs (NSAIDs) are traditionally used to alleviate arthritis symptoms, long-term use is often problematic. NSAIDs may cause adverse gastrointestinal or cardiovascular effects, disrupt the immune system or be ineffective at reducing the pain.9

Of the limited Instaflex complaints, users note the side effects listed above. For users that are pregnant, nursing, or have a serious medical condition, consult with a health care practitioner to avoid any possible Instaflex drug interactions.

Does Instaflex Work?

Below, we take a look at the latest scientific evidence for the key ingredients in Instaflex.

For users with stiff knees or knee osteoarthritis, glucosamine, Boswellia serrata and hyaluronic acid have been shown to be effective ingredients.4,11,12 In one study, 50 volunteers with knee pain were given 2000 mg of glucosamine for 12 weeks. Results show that 88% of the participants reported less discomfort in their knees and improved flexibility.4 When taken daily for two months at a time, both hyaluronic acid and Boswellia serrata extract have been shown to significantly improve in knee flexibility, walking distance and reduce joint pain.11,12

MSM has also been widely used to alleviate inflammation and joint pain. In a 2006 study, 50 patients with knee osteoarthritis were given MSM twice a day for 12 weeks. It was concluded that taking MSM daily, significantly improved symptoms of pain and discomfort, and improved physical function of the knee.13

Is Instaflex good for arthritis? – Instaflex may be useful for natural arthritis relief. Both glucosamine and MSM are used to treat a variety of conditions, such as osteoarthritis and other inflammatory joint complaints.4,5

White willow bark is commonly used in Europe to naturally mange pain. In one clinical trial, patients who experienced chronic low back pain were given either a low dose (120 mg) or a high dose (240 mg) of willow bark for 4 weeks. Researchers noted that 39% of patients in the high dose group were pain-free, with many patients noticing results within the first week.14 Instaflex contains a slightly higher dose, with 250 mg per serving.

Studies that have been conducted on using ginger extract, turmeric and cayenne have also shown beneficial effects for users with osteoarthritis or joint discomfort. When used as a supplement for 3 months, ginger extract reduced swelling and pain in osteoarthritis subjects.15 Studies on middle-aged patients with joint pain have also noted a decrease in pain and inflammation when taking turmeric for at least four weeks. Cayenne may also be effective in alleviating inflammation.9,10

Instaflex Reviews

Reviews on Instaflex show a positive response to the product. Many reviewers comment on how Instaflex helped relieve their joint pain, and gave them more mobility and flexibility.

Some Instaflex joint support reviews report that the stiffness in their joints has lessened, allowing them to engage in sports and activities they haven’t been able to do for years. Many people who have used the supplement for one month continued to purchase the product due to the positive effects.

Where to Buy Instaflex

Users can purchase Instaflex in stores, as well as online from the distributor’s website or through Amazon. For stores that carry Instaflex, GNC, Walgreens, and CVS are popular choices.

How Much Does Instaflex Cost?

At GNC, a 90-capsule bottle of Instaflex is available for $59.99. Instaflex pills are also available in a smaller pack on the product website. For the cost of shipping and handling, users receive a two-week supply to determine if Instaflex is right for them.

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Scientific Research Referenced in this Article

  1. GNC. (n.d.). INSTAFLEX® JOINT SUPPORT. Retrieved December 01, 2017 from – View Reference
  2. Instaflex. (n.d.). Instaflex. Retrieved December 01, 2017 from – View Reference
  3. Priebe, D. & McDiarmid, T. (2003) Do glucosamine or chondroitin cause regeneration of cartilage in osteoarthritis. J Fam Pract, 52(3), 229-239. Retrieved December 01, 2017 from http://www.mdedge.com/jfponline/article/59438/rheumatology/do-glucosamine-or-chondroitin-cause-regeneration-cartilage
  4. Braham, R. & Dawson, B. (2003) The effect of glucosamine supplementation on people experiencing regular knee pain. British Journal of Sports Medicine, 37(1), 45-49. doi: 1136/bjsm.37.1.45
  5. Brien, S. & Prescott, P. (2011) Meta-Analysis of the Related Nutritional Supplements Dimethyl Sulfoxide and Methylsulfonylmethane in the Treatment of Osteoarthritis of the Knee. Evid Based Complement Alternat Med. 2011: 528403. doi: 1093/ecam/nep045
  6. Altinterim, B. (2013) Effects of Willow Bark (Salix alba) and Its Salicylates on Blood Coagulant. Karaelmas Science and Engineering Journal. 3: 37-39. Retrieved on December 01, 2017 from https://www.researchgate.net/publication/268515420_Effects_of_Willow_Bark_Salix_alba_and_Its_Salicylates_on_Blood_Coagulant
  7. Mashhadi, N.S. & Ghiasvand, R. (2013) Anti-Oxidative and Anti-Inflammatory Effects of Ginger in Health and Physical Activity: Review of Current Evidence. Int J Prev Med. 4(Suppl 1): S36-S42. Retrieved on December 01, 2017 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665023/
  8. Siddiqui, MZ. (2011). Boswellia Serrata, A Potential Antiinflammatory Agent: An Overview. Indian J Pharm Sci. 73(3): 255-261. Retrieved on December 01, 2017 from https://www.ncbi.nlm.nih.gov/pubmed/22457547
  9. Daily, J. & Yang, M. (2016). Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical J Med Food, 19(8), 717-729. doi:  10.1089/jmf.2016.3705
  10. Seca, S. & Geada, L. (2017). Topical Effects of Capsicum frutescens on Hand Pain in Patients with Rheumatoid Arthritis: A Case Report. J Tradit Med Clin Natur. 6, 204. Retrieved December 01, 2017 from https://www.omicsonline.org/open-access/topical-effects-of-capsicum-frutescens-on-hand-pain-in-patients-withrheumatoid-arthritis-a-case-report.php?aid=84990
  11. Oe, M., Tashiro, T., Yoshida, H., Nishiyama, H., Masuda, Y., Maruyama, K., … Fukui, N. (2015). Oral hyaluronan relieves knee pain: a review. Nutrition Journal15(1). doi:1186/s12937-016-0128-2
  12. Kimmatkar, N. & Thawani, V. (2011). Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee–a randomized double-blind placebo controlled trial. Phytomedicine. 10(1): 3-7. Retrieved on December 01, 2017 from https://www.ncbi.nlm.nih.gov/pubmed/12622457
  13. Kim, LS. & Axelrod, LJ. (2006). Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis and Cartilage, 14(3), 286-294. https://doi.org/10.1016/j.joca.2005.10.003
  14. Chrubaski, S. & Eisenberg, E. (2000). Treatment of low back pain exacerbations with willow bark extract: a randomized double-blind study. Am J Med, 109(1): 9-14. Retrieved on December 01, 2017 from https://www.ncbi.nlm.nih.gov/pubmed/10936472
  15. Bode, A. & Z. Dong. (2011) Chapter 7 – The Amazing and Mighty Ginger. Herbal Medicine: Biomolecular and Clinical Aspects, 2nd Retrieved on December 01, 2017 from https://www.ncbi.nlm.nih.gov/books/NBK92775/

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